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Speakers Biographies Elstein, Dr. Michael | Faragher, Dr. Richard | Flanary, Mr. Barry | Fossel, Dr. Michael | Francis, Dr. Andrew J.P | Gavrilov, Dr. Leonid | Gavrilova, Dr. Natalia | Greville, Dr. Warwick | Hayflick, Prof. Leonard | Holliday, Dr. Robin | Ingram, Dr. Donald | Joseph, Dr. James | Kalache, Dr. Alexandre | King, Ms. Petrea | Kril, Assoc. Prof. Jillian | Le Couteur, Prof. David | Linnane, Prof. Tony
Dr. Michael Elstein is a physician
practising at the Spa Chakra Wellness Centre in Woolloomooloo. Present post: Principal School Fellow, School of Pharmacy and Biomolecular Sciences, Cockcroft Building, University of Brighton, Brighton, Sussex. Present Duties Managerial Research Strategy Group 2001-date. This committee
fulfils an advisory role to the Head of School. It deals with the allocation
of all QR funds and overheads, and develops and reviews strategies to
enhance research excellence within the School. Responsible for developing
the School Research Strategy Guide that formalises the application process
for QR support and provides an output monitoring mechanism. More recently
I designed and implemented an annual Staff Research Review (SRR) process
that runs alongside our normal Staff Appraisal. The Head of School requested
that this be instigated in order to maximise our competitiveness for
RAE 2007. School Safety Committee Member, University of
Brighton 1999-date REFEREES Dr Richard Aspinall, Dept of Immunology, Faculty of Medicine, Imperial College of Science Technology &Medicine, Chelsea & Westminster Hospital, 369 Fulham Road, London. SW10 9NH. Tel: 020 8746 5993. Fax: 020 8746 5997 Email: r.aspinall@ic.ac.uk Professor Stephen Denyer, School of Pharmacy & Biomolecular Sciences, Cockcroft Building, University of Brighton, Brighton BN2 4GJ. Tel: 01273 642100. Fax: 01273 679333. Email: S.P.denyer@brighton.ac.uk EMPLOYMENT 2000-2003 Senior School Fellow, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, Sussex. 1997-2000 School of Pharmacy and Biomolecular
Sciences, University of Brighton, Brighton, Sussex. Special appointment
as tenure-track School Research Fellow with brief to establish a gerontology
research group. First such appointment made by the School. 1992- 1993 Trafford Centre for Medical Research,
University of Sussex, Falmer, Sussex. Temporary Research Assistant working
on the DNA repair and senescence of fibroblasts from the accelerated
ageing disease Hutchinson-Guilford Progeria.
He is a member of the American Aging Association and the Gerontological Society of America, and was an undergraduate research Fellow in a National Science Foundation research training program under a grant received by ISU; twice he received a graduate student association research grant while working on his Master's thesis: "Molecular cloning, characterization, and mutagenesis of the msbB gene, a secondary lipid A acyltransferase, in Haemophilus parainfluenzae. During work on his M.S., he received one teaching fellowship and one research fellowship. Thus far while working on his Ph.D. thesis, he has served as a graduate student mentor, was competitively selected for and attended a National Institute on Aging Technical Assistance Workshop for Emerging Scientists and Students Seeking Careers in Aging Research, he co-authored a grant received from the Evelyn F. McKnight Brain Research Foundation at UFL, received one graduate student council grant from UFL, one department of Neuroscience grant from UFL, two medical guild research incentive awards from UFL, three fellowships from the American Foundation for Aging Research, one fellowship from the Neurobiology of Aging program at UFL, and two endowments from the Bryan W. Robinson Memorial Endowment for the Neurosciences of the Tallahassee Memorial Hospital Foundation, Inc. at Florida State University. Mr. Flanary has served as a Phi Sigma grant review committee member and as a graduate teaching assistant in introductory Biology for one year and introductory Microbiology for one semester at ISU. From 1999 to 2001, he has had ongoing involvement
as chief scientific advisor for a telomere-based art project at Art
to the Nth Power Inc., a collaborative art group and media lab based
in Chicago, IL. Mr. Flanary has presented both his undergraduate and
graduate research at numerous local, regional, and national research
symposia since 1997. His current Ph.D. thesis research focuses on the
roles that telomere shortening and cell senescence in microglia and
astrocytes play in Alzheimer's disease. His publications through 2003
include 13 abstracts, 16 literature and book reviews, one book chapter,
and 3 full-length research articles. Born in 1950 in Greenwich, Connecticut in the United States, Michael Fossel grew up New York, and lived in London, Palo Alto, San Francisco, Portland, and Denver. He graduated cum laude from Phillips Exeter Academy, received a joint BA (cum laude) and MA in psychology in four years from Wesleyan University in Connecticut, and, after completing a PhD in neurobiology at Stanford University in 1978, went on to finish his MD at Stanford Medical School in two and a half years. He was awarded a National Science Foundation Fellowship and taught at Stanford University, where he began studying aging, emphasizing premature aging syndromes. Dr. Fossel is a Clinical Professor of Medicine at Michigan State University. He is a Fellow of the American College of Emergency Physicians, and a member of numerous scientific organizations including the American Association for the Advancement of Science, the American Aging Association (and serves on their board of directors), the American Gerontological Society, the American Society on Aging, and the American Geriatrics Society, among others. He has lectured at the National Institute for Health, the Smithsonian Institute, and at universities and institutes internationally. He is also editor-in-chief of the Journal of Anti-Aging Medicine. His numerous articles on aging and ethics in the Journal of the American Medical Association, In Vivo, and elsewhere have sparked discussion and frequent calls for him to speak worldwide to both medical groups and the general public. He is frequently interviewed regarding aging by major media in the US and worldwide. In 1996, Dr. Fossel published Reversing Human Aging, discussing the cellular causes of aging, how the process can be altered, and the social and financial implications of reversing human aging. The book was reviewed favorably in national full page newspaper articles and in Scientific American. It has now been published in six languages. He has appeared on Good Morning America, ABC 20/20, NBC Extra, Fox Network, CNN, the BBC, the Discovery Channel, and regularly on NPR. He is currently working on an academic text
titled "Cells, Aging, and Human Disease", due for publication
in 2003 by Oxford University Press. An extensive look at the field,
with well over four thousand up-to-date references, it reviews the entire
fields of telomere biology and cell senescence as they apply to human
clinical diseases and aging. It includes in depth discussions of Alzheimer's
disease, the progerias, atherosclerosis, osteoporosis, immune senescence,
skin aging, and cancer, as well as the potential for fundamentally new
therapies for these diseases.
Senior Lecturer in Psychology Dr. Andrew Francis is a Chronobiologist and Psychologist, and is currently completing a degree in Herbal Medicine. As well as interests in general psychopathology, he conducts clinical trials investigating the efficacy of herbal medicines and exercise for alleviation of psychobehavioural problems across the lifespan. His most recent work has focussed on herbal and exercise treatments for improving sleep and mood in older adult populations. Title of Talk Leonid A. Gavrilov, Ph.D. is the author of a famous
and widely cited He is a Principal Investigator of the scientific
project "Biodemography of Dr. Gavrilov is the Editorial Board member of
scientific journals He also acted as an Expert for the National Institute
on Aging (USA), the His scientific credentials are described in more
detail in "Who's Who in Dr. Gavrilov is the founder of a new reliability
theory of aging, which has Dr. Leonid Gavrilov works at the Center on Aging, National Opinion Research Center, University of Chicago. My full CV is available at: Natalia S. Gavrilova, Ph.D. is a co-author of
a famous and widely cited Dr. Gavrilova was a Principal Investigator of
Research Project "Biodemographic aspects of longevity inheritance
in humans" supported by She also participated in the NASA project ""Radiation
Risk Analysis:Model Dr Natalia Gavrilova is an author of nearly a
hundred of scientific Her current research interests include application
of advanced computer Dr. Gavrilova works at the Center on Aging, National
Opinion Research My detailed CV is available at:
Dr. Hayflick was born on 20 May 1928 in Philadelphia, Pa. His formal higher education was obtained at the University of Pennsylvania where he received the Ph.D. in 1956. After receiving a post-doctoral Fellowship for study at the University of Texas, Galveston, he returned to Philadelphia, where he spent ten years as an Associate Member of the Wistar Institute and two years as an Assistant Professor of Research Medicine at the University of Pennsylvania. In 1968 Dr. Hayflick was appointed Professor of Medical Microbiology at the Stanford University School of Medicine, Stanford, California. In 1982 he moved to the University of Florida, Gainesville, where he became Director of the Center for Gerontological Studies and Professor of Zoology in the College of Liberal Arts and Sciences and Professor of Microbiology and Immunology in the College of Medicine. In 1988 Dr. Hayflick joined the faculty of the University of California, San Francisco where he is presently Professor of Anatomy. Dr. Hayflick is a member of numerous national and international scientific and public boards of directors and committees. He is now, or has been, on the Editorial Boards of more than ten professional journals. Dr. Hayflick was Editor-in-Chief of the international journal "EXPERIMENTAL GERONTOLOGY" for 13 years. He is a member of twenty scientific and professional societies in which he has held several high offices including President of the Gerontological Society of America from 1982 to 1983. He was a founding member of the Council of the National Institute on Aging, NIH and Chairman of it's Executive Committee. He was a consultant to the National Cancer Institute, the World Health Organization and is now a member of several scientific advisory boards and study sections. He was Chairman of the Scientific Review Board of the American Federation for Aging Research where he was also a Vice President and is now a Member of the Board of Directors. Dr. Hayflick developed the first normal human diploid cell strain for studies on human aging and for research use throughout the world wherever a normal human cell is required. One cell strain, developed by Dr. Hayflick and called WI-38, is the most widely used and highly characterized normal human cell population in the world. Hayflick produced the first oral polio vaccine made on a continuously propagable cell strain. WI-38 is now used for the production of all of the Rubella Virus vaccine used in the Western Hemisphere. WI-38, or its imitators, is used today for the manufacture of most human virus vaccines produced throughout the world including those for poliomyelitis, rubella, rubeola, rabies and adenoviruses. Over 750 million vaccinees have received vaccines produced on WI-38 or similar diploid cell strains. Dr. Hayflick is also known for his discovery of the cause of primary atypical pneumonia ("Walking Pneumonia") in humans. The etiological agent was first thought to be a virus, but Dr. Hayflick showed that it was, in fact, a mycoplasma, a member of the smallest free-living class of microorganisms. The etiological agent was named by him as Mycoplasma pneumoniae, and was first grown by Hayflick on a medium he developed and that bears his name. It is now used world wide for mycoplasma isolation and research. Dr. Hayflick is the recipient of more than twenty-five major awards including the $20,000 Brookdale Award and the Kleemeier Award from the Gerontological Society of America, the Biomedical Sciences and Aging Award from the University of Southern California, The Karl August Forster Lectureship of the Academy of Sciences and Literature and the University of Mainz, Germany, the Samuel Roberts Nobel Foundation Research Recognition Award, the Lifetime Achievement Award of the Society for In Vitro Biology, the Sandoz Prize from the International Association of Gerontology, and the Presidential Award from the International Organization of Mycoplasmology. In 1997, Hayflick was elected Academician and Foreign Member of the Ukrainian Academy of Medical Sciences. In 1998 he was elected corresponding member of the Société de Biologie of France. In 1999 he was presented with the van Weezel Award by the European Society for Animal Cell Technology and the Lord Cohen of Birkenhead Medal by the British Society for Research on Aging. In 1997 the American Aging Association established an Annual Hayflick Lecturship. A second Annual Hayflick Lecture also was established in 2000 by the University of Alabama, Birmingham. Hayflick is the recipient of the year 2001, $10,000 Life Extension Prize and Laureate Diploma from the Regenerative Medicine Secretariat for his "..discovery of the finite replicative capacity of normal human diploid cells.." Hayflick is a Fellow of the American Association for the Advancement of Science, an Honorary Member of the Tissue Culture Association and, according to the Institute of Scientific Information, is one of the most cited contemporary scientists in the world in the fields of biochemistry, biophysics, cell biology, enzymology, genetics and molecular biology. Dr. Hayflick is the author of over 250 scientific papers, book chapters and edited books of which four papers are among the 100 most cited scientific papers of the two million papers published in the basic biomedical sciences from 1961 to 1978. Dr. Hayflick is the author of the popular
book, "How and Why We Age" published in August 1994 by Ballantine
Books, NYC and available in 1996 as a paperback. This book has been
translated into nine languages and is published in Japan, Brazil, Russia,
Spain, Germany, the Czech Republic, Poland, Israel and Hungary. It was
a selection of The Book-of-the-Month Club. Robin Holliday obtained his Ph.D. at the
University of Cambridge, England. He joined the scientific staff of
the John Innes Institute, Bayfordbury, Hertford, in 1958, and there
developed molecular models of genetic recombination. In experimental
work he studied recombination and repair in the fungus Ustilago maydis
and was the first to isolate and characterise mutants defective in these
processes in any eukaryotic organism. He later moved to the National
Institute for Medical Research at Mill Hill, London, and became head
of the new Division of Genetics in 1970. He was elected Fellow of the
Royal Society of London in 1976. He and his colleagues also studied
possible mechanisms of the senescence of diploid human cells in culture,
and their immortalisation. In 1975 he suggested with his student John
Pugh that DNA methylation could be an important mechanism for the control
of gene expression in higher organisms, and this has now become documented
as a basic epigenetic mechanism in normal and also cancer cells. In
1988 he moved to a CSIRO laboratory in Sydney, Australia, where he continued
to study ageing, and his book Understanding Ageing was published in
l995. The main focus of his experimental work was the epigenetic control
of gene expression by DNA methylation in CHO cells. These experiments
provide direct evidence that DNA methylation is a primary cause of gene
silencing in mammalian cells.
Research Interests: The Behavioral Neuroscience Section (BNS) is dedicated to the study of cellular and molecular mechanisms responsible for age-related changes in behavioral function. A variety of rat and mouse models are examined in a battery of behavioral tests with primary emphasis on memory and motor performance. Biochemical assays are used to determine alterations in neurotransmitter receptor and enzyme function related to age-related behavioral impairments. Microdialysis is used to provide in vivo sampling of neurotransmitter release in specific brain loci. Morphometric analysis is conducted using unbiased stereology to determine if functional alterations can be linked to age-related changes in the number of specific populations of neurons and their connections as well as changes in neuroglia. Genetic analysis is pursued using cDNA microarray technology to link gene expression to behavioral impairments. The section is also actively involved in identifying various interventions to alter age-related functional declines and neurodegeneration. Initiatives in pharmacologic intervention have focused on indirect stimulation of the cholinergic and glutamatergic neurotransmitter systems to enhance memory performance. Initiatives in gene therapy have focused on developing an adenoviral vector for intracerebral delivery of neurotransmitter receptors in enhance motor performance. Another major initiative has involved investigating the beneficial effects and anti-aging mechanisms of long-term calorie restriction. CR mimetics Sci Am paper (pdf file) Lead Scientist~USDA / Chief Neuroscience Laboratory SELECTED PAPERS (out of 172)
Currently, he is Chief of the Ageing and Life Course Programme (ALC) at the World Health Organization. ALC is designed to advance the state of knowledge about health care in old age and gerontology through special training and research efforts, in addition to ensuring information dissemination and policy development. ALC special focus is on the development of the 'Active Ageing' framework. Previously, Dr Kalache served as founder and head of the Epidemiology of Ageing Unit at the London School of Hygiene and Tropical Medicine (LSHTM), where from 1984 to 1995, he launched a series of international short courses on the implications for Public Health of population ageing, which were subsequently adapted by several countries around the world. While at the LSHTM Dr Kalache was also responsible for setting up, in 1991, the first European MSc course on Health Promotion. The framework adopted for this initiative was used as a base for the development of the WHO Programme he has coordinated since 1995 and which incorporates a strong healthy ageing/life course perspective. From 1978 - 1984 Dr Kalache was a clinical lecturer at the Department of Social Medicine, Oxford University. In 1978 he was inducted as a Public Health Fellow of the Royal College of Physicians, London. He first became interested in ageing issues while studying for his Master of Science degree in Social Medicine at the University of London ( 1975-1977 ). Early in his career, after his medical graduation
in Rio de Janeiro, his home town, Dr Kalache was an assistant lecturer
in clinical medicine with a special interest on infectious diseases
and on medical education.
Since her recovery from leukaemia in 1984, Petrea King has brought her warmth, humour and wisdom to thousands of people with cancer and other serious illnesses and to people living with loss of meaning, grief, depression, anxiety or tragedy. Petrea holds qualifications in naturopathy, herbal medicine, homeopathy, clinical hypnotherapy, massage and is a qualified teacher of meditation and yoga. She has written three books and produced twenty relaxation and meditation audio-tapes and CD's to assist people in finding peace in the midst of life-challenges. In 1990 she established the Quest for Life Foundation which now owns and operates the Quest for Life Centre in Bundanoon. It is in this thirty-bed guesthouse, set in nine tranquil acres of gardens, that the residential programs, counselling and other services are conducted. More than 50,000 people have passed through her programs or sought counselling with her. Petrea has received the Advance Australia
Award and the Centenary Medal for her contribution to the community.
She addressed the National Press Club in 1996 on National Breast Cancer
Day and is a frequent guest on ABC radio with Richard Glover (Mid-Week
Conference) and Tony Delroy and in other media. Associate Professor of Geriatric Medicine at The University of Sydney's Centre for Education and Research on Ageing which is located at Concord Hospital. Her area of interest is the neuropathology of ageing and dementia. Jillian completed her undergraduate training in pathology at the University of Western Australia and her PhD at The University of Sydney. Her early work focussed on the neuropathology of alcohol-related brain damage. However, her interest in the pathological substrates of brain dysfunction led her to the study of dementia. In particular Jillian is interested in clinicopathological correlations and has worked towards an understanding of the regional susceptibility of neuronal populations in Alzheimer's disease, frontotemporal dementia and other forms of dementia. A necessary component of studying the neuropathology of dementia is the investigation of brain ageing and Jillian and her colleagues have performed a number of studies examining brain size and neuronal number in ageing. This work has shown that brain atrophy and neuronal loss are not a major feature of normal ageing. An integral part of Jillian's work has been the establishment of a brain donor program which is jointly co-ordinated with Professor Glenda Halliday from the Prince of Wales Medical Research Institute. This program recruits longitudinally followed patients with dementia and movement disorders into the neuropathology research program and has close links with Geriatricians and Neurologists throughout New South Wales. Jillian is the Vice President of the Ageing
and Alzheimer's Research Foundation and an active member of the Australian
Neuroscience Society and the Australian and New Zealand Society for
Neuropathology. Jillian was awarded the AW Campbell Award for her contribution
to neuroscience in 1999. Professor of Geriatric Medicine at the University of Sydney and Senior Staff Specialist in Geriatric Medicine at the Concord RG Hospital. He is Director of the Centre for Education and Research on Ageing (CERA). His research interests include the biology of ageing with a particular focus on the ageing liver and disease susceptibility.
Managing Director, Centre for Molecular Biology & Medicine Epworth Medical Centre Honours Positions Held Research Accomplishments And Contributions Publications Organisational Offices Committee & Organisational Activities:
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Dr.
Michael Elstein 
Dr. Richard Faragher 
Barry E. Flanary, M.S.
Michael Baird Fossel, MD, PhD
Leonid A. Gavrilov, Ph.D.
Natalia S. Gavrilova, Ph.D.
Dr. Warwick L. Greville
Leonard Hayflick, Ph.D.
Robin Holliday
Donald K. Ingram, Ph.D., Senior Investigator
James A. Joseph 
Alexandre Kalache (MSc, MD, PhD, FRCPH)
Petrea King, N.D., D.B.M., D.R.M., Dip C. Hyp., I.Y.T.A.
Prof.
David Le Couteur
Anthony
William Linnane. AM. PhD. DSc. FRS. FAA. FTSE.